氯前列烯醇是PGF2α類似物，在目前常用的PGF2α及其類似物中，它的活性高。

D-cloprostenol  sodium (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch^[1].

D-Cloprostenol sodium and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and about 280 times more potent than PGE1 in inhibiting [³H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and about 95 times more potent than PGE1 in myometrial cell membranes^[2].