Recombinant Human Oncostatin M 貨號:300-10細胞因子
胞因子受體存在著可溶性形式，掌握可溶性細胞因子受體產(chǎn)生的規(guī)律及其生理和病理意義，必將擴展人們對細胞因子網(wǎng)絡(luò)作用的認識。檢測細胞因子及其受體的水平已成為基礎(chǔ)和臨床免疫學研究中的一個重要的方面。Catalog Number:
Catalog Number:
300-10
Synonyms:
OSM
Description:
Oncostatin M （OSM） is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release （e.g. IL-6, GM-CSF and G-CSF） from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 26.0 kDa protein, containing 227 amino acid residues.
AA Sequence:
MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR TRPSRKGKRL MTRGQLPR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Cross Reactivity:
Dog, Monkey, Mouse, Pig, Rat, Human
Research Interests:
 | AIDS / HIV |  | Angiogenesis/ Cardiovascular |
 | Bone, Skeletal, Cartilage |  | Immune System |
 | Inflammation |  | Stem Cells & Differentiation |
Country of Origin:
USA
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