L-Carnitine (Synonyms: 左旋肉堿; (R)-Carnitine; Levocarnitine)
L-Carnitine 是一種高度極性的小兩性離子，是線粒體β-氧化途徑的重要共因子。L-Carnitine 的作用是將長鏈脂肪?；o酶- A 轉(zhuǎn)運到線粒體中，通過 β-氧化降解。L-Carnitine 是一種抗氧化劑。L-Carnitine 可以改善許多先天性代謝錯誤的代謝失衡。
生物活性
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism
IC50 & Target
Human Endogenous Metabolite
體內(nèi)研究(In Vivo)
L-Carnitine ((R)-Carnitine) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion
分子量：161.20
Formula：C7H15NO3
CAS 號：541-15-1
中文名稱：左旋肉堿
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
4°C, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性數(shù)據(jù)
H2O : ≥ 50 mg/mL (310.17 mM)
* "≥" means soluble, but saturation unknown.
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.2035 mL | 31.0174 mL | 62.0347 mL |
| 5 mM | 1.2407 mL | 6.2035 mL | 12.4069 mL |
| 10 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
參考文獻(xiàn)
[1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5.
[2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.
[3]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.
注：產(chǎn)品僅用于科研
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