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Lipopolysaccharides試劑

參考價	￥1320.00-￥4800.00

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公司名稱杭州昊鑫生物科技股份有限公司
品牌MCE
型號HY-D1056
所在地杭州市
廠商性質代理商
更新時間2023/5/25 15:08:11
訪問次數648

產品標簽:

Lipopolysaccharides 脂多糖 LPS

規(guī)格

5 mg	1320.00元	10000 件可售
10 mg	2200.00元	10000 件可售
25 mg	4800.00元	10000 件可售

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杭州昊鑫生物科技股份有限公司成立于2009年初，是一家面向生命科學領域，從事科研機構、高校、院所及生產企業(yè)所需科研試劑、耗材，儀器銷售和服務面向全國。

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產地	進口	級別	其他

Lipopolysaccharides試劑脂多糖是從革蘭氏陰性菌外膜的外葉中提取的內毒素，由一個抗原 O- 特異性鏈、一個核心寡糖和脂質 A 構成。Lipopolysaccharides 是一種激活免疫系統(tǒng)的致病相關分子模式 (PAMP)。Lipopolysaccharides 激活免疫細胞的 TLR-4。本產品來源于大腸桿菌 O55:B5

Lipopolysaccharides試劑產品信息

注：本產品僅用于科研，不可用于臨床

Lipopolysaccharides試劑生物活性

ipopolysaccharides (LPS)是一種內毒素來源于外層膜的外膜革蘭氏陰性細菌。脂多糖由抗原O-specific鏈,一個核心的低聚糖和脂質a脂多糖是一種病原相關分子模式(PAMP時),激活免疫系統(tǒng)。脂多糖對免疫細胞激活地[1][2][3]。這個產品來源于大腸桿菌O55: B5。脂多糖誘導的分泌細胞migrasome

Lipopolysaccharides試劑 IC₅₀ & Target

TLR4

體外研究
(In Vitro)

Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production)^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內研究
(In Vivo)

Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female and male CD1 mice^[3]
Dosage:	1.5mg/kg
Administration:	Intraperitoneal injection, once
Result:	Induced sickness behavior in all mice, but adult mice displayed more sickness than pubertal mice and adult males remained sick for a longer period of time than adult females. Caused a decrease in body temperature for all mice, but this decrease was greatest in adult males. Increased pro- and anti-inflammatory cytokines at various levels in pubertal and adult male and female mice, resulted in age and sex differences in cytokine concentrations following immune challenge. Only adult males and females treated with LPS displayed significantly more IL-6 than their saline controls, and pubertal males and females and adult females displayed significantly more IL-10 than their saline controls. All the mice displayed significantly more IL-12 and TNF-α than their saline controls.

性狀

Solid

中文名稱

脂多糖

結構分類