腫瘤癌癥細(xì)胞的光熱和光動(dòng)力治療的熒光染料

Certificate of Analysis

 General properties:

 Name：IR825

 Molecular Weight：823.4 Dalton

 Molecular Formula :  C54H48CIN2O4

CAS.#：1558079-49-4

 Lot.#： RM017172

 Date of Analysis：2018.01.09

 Recommended Retest date：2019.01.09

 Stability： 12 months

 Storage： -20°C in the dark

腫瘤癌癥細(xì)胞的光熱和光動(dòng)力治療的熒光染料

IR-825 is a near-infrared dye (NIR). IR-825, after encapsulated into nanoparticles may be useful for cancer photothermal and photodynamic therapy. IR-825 nanoparticles showed pH-dependent fluorescence emission and excellent near-infrared (NIR) irradiation of cancer cells targeted in vitro to provide cytotoxicity. IR-825 nanoparticles showed efficient tumor homing together with rapid renal excretion behaviors, as revealed by MR imaging and confirmed by biodistribution measurement. Notably, when irradiated with an 808 nm laser, tumors on mice with IR-825 nanoparticle injection are compley eliminated without recurrence within 60 days, demonstrating the high efficacy of photothermal therapy.

杭州新喬生物科技有限公司可以提供一種用于腫瘤癌癥細(xì)胞的光熱治療和光動(dòng)力治療的近紅外熒光染料IR-825，該產(chǎn)品的吸收波長(zhǎng)是810nm,發(fā)射波長(zhǎng)是830nm,該產(chǎn)品的末端帶有羧基COOH活性基團(tuán)可以參與反應(yīng)連接其他分子，這個(gè)產(chǎn)品的造價(jià)要低于ICG-COOH，可以廣泛用于腫瘤的光熱治療。我公司制備的IR-825純度95.4%，可以溶解在二氯甲烷、甲醇、DMF、DMSO里。

特別說明：該產(chǎn)品僅僅用于科學(xué)研究，不用于人體及藥物開發(fā)