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The English Introduction

Bis-sulfone NHS Ester is a unique heterobifunctional building block with amine and sulfhydryl/thiol reactivity that overcomes the drawbacks associated with the use of traditional sulfhydryl labeling chemistry. Traditional sulfhydryl labeling chemistry cleaves disulfide bridges and leaves them in “open form”, which may compromise the stability and function of an antibody or other proteins. Bis-sulfone reagents re-bridge the disulfide bond, and enhance the structural stability of the protein.

Molecular weight	597.66
Chemical composition	C29H27NO9S2
CAS	899452-51-8
Solubility	DMSO, DMF, DCM, THF, Chloroform
Purity	>95% (HPLC)
Appearance	White crystalline
Storage conditions	-20C
Shipping conditions	Ambient temperature

Click Chemistry Tool

DBCO Reagents

Amine Reactive

DBCO-C6-NHS Ester

• DBCO-NHS Ester
• DBCO-Sulfo-NHS Ester
• DBCO-PEG4-NHS Ester
• DBCO-PEG5-NHS Ester
• DBCO-PEG13-NHS Ester
• PC DBCO-NHS Ester
• DBCO-C6-Acid
• DBCO-Acid
• DBCO-PEG5-Acid

Carboxyl/Carbonyl Reactive

• DBCO-Amine
• DBCO-PEG4-Amine
• Sulfo DBCO-PEG4-Amine
• Sulfo DBCO-Amine

 Sulfhydryl Reactive

• Sulfo DBCO-Maleimide

DBCO-Maleimide

• Sulfo DBCO-PEG4-Maleimide
• DBCO-PEG4-Maleimide
• Bis-sulfone-PEG4-DBCO
• ThioLinker-DBCO

Fluorescent Probes

• MB 532 DBCO

MB 488 DBCO

• MB 543 DBCO
• MB 594 DBCO
• Carboxyrhodamine 110 DBCO
• TAMRA DBCO
• Cy3 DBCO
• Cy5 DBCO
• Cy5.5 DBCO
• Cy7 DBCO

 Biotinylation Reagents

• DBCO-PEG4-Biotin

WS DBCO-Biotin

• DBCO-PEG4-Desthiobiotin
• Dde Biotin-DBCO
• PC DBCO-Biotin
• WS PC DBCO-Biotin
• Diazo Biotin-DBCO

PEGylation Reagents

• DBCO-mPEG, 5 kDa

DBCO-mPEG, 10 kDa

• DBCO-mPEG, 20 kDa
• DBCO-mPEG, 30 kDa

 Bifunctional Crosslinkers

• Methyltetrazine-DBCO

Methyltetrazine-PEG12-DBCO

• DBCO-PEG4-DBCO
• TCO-PEG12-DBCO

 Miscellaneous Reagents

• DBCO-PEG4-Hydroxyl

中文介紹

Bis-sulfone NHS Ester，硫醇反應(yīng)性克服了傳統(tǒng)巰基標(biāo)記化學(xué)的缺點(diǎn)。傳統(tǒng)的巰基標(biāo)記化學(xué)方法會(huì)將二硫醚橋接在一起，使橋接體保持開放狀態(tài)，這可能會(huì)影響抗體或其他蛋白質(zhì)的穩(wěn)定性和功能。Bis-sulfone試劑重新橋接二硫鍵，增強(qiáng)蛋白質(zhì)的結(jié)構(gòu)穩(wěn)定性。

分子量	597.66
分子式	C29H27NO9S2
CAS	899452-51-8
溶解度	DMSO, DMF, DCM, THF, Chloroform
含量	>95% (HPLC)
外觀	白色透明晶體
儲(chǔ)存	-20C
運(yùn)輸	環(huán)境溫度

西安凱新生物科技有限公司是國(guó)內(nèi)的功能化PEG修飾納米金及納米金棒的供應(yīng)商，我們可以提供多達(dá)十幾種的活性基團(tuán)及各種不同的蛋白分子或聚合物。我公司能和PEG通過(guò)雙硫鍵偶連的Gold Nanorods的LSPR從600nm-1000nm不等，我們偶連的PEG末端帶有功能活性基團(tuán)可以和NH2，MAL，COOH，SH，NHS活化連接不同的蛋白或分子。

 

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