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Recombinant Human VEGF165 貨號:100-20 細(xì)胞因子

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Recombinant Human VEGF165 貨號:100-20 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn):多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human VEGF165 貨號:100-20 細(xì)胞因子

 

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征,可將細(xì)胞因子受體主要分為四種類型:免疫球蛋白超家族(IGSF)、造血細(xì)胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

 

Catalog Number:
100-20
Synonyms:
Vascular Endothelial Growth Factor, VPF, Folliculoslate cell-derived growth factor, Glioma-derived endothelial cell mitogen
Description:
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human VEGF165 is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
AA Sequence:
APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.
 
 
 
 
Cross Reactivity:
Cow, Green Algae, Guinea Pig, Hamster, Mouse, Pig, Rabbit, Rat, Sheep, Trout, Human, Chicken, Leech, Zebra Fish Embryo, Gelatin Microparticles, Rat + Chicken
Research Interests:
Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular Cancer Cancer
Inflammation Inflammation Proliferation Proliferation
 
 
Country of Origin:
USA


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