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Recombinant Murine IL-6 貨號:216-16 細(xì)胞因子

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Recombinant Murine IL-6 貨號:216-16 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Murine IL-6 貨號:216-16 細(xì)胞因子  

 

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細(xì)胞因子受體主要分為四種類型：免疫球蛋白超家族（IGSF）、造血細(xì)胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

 

Catalog Number:
216-16
Synonyms:
26 kDa protein, IFN-b2, B cell differentiation factor （BCDF）, BSF-2, HPGF, HSF, MGI-2
Description:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and plaet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
AA Sequence:
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is ≤ 0.02 ng/ml, corresponding to a specific activity of ≥ 5 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Monkey, Mouse, Trout, Human, Rat, N/A, Mouse + Bacteria
Research Interests:
Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular Cancer Cancer
Cell Culture Cell Culture Diabetes / Weight Regulation Diabetes / Weight Regulation
Immune System Immune System Inflammation Inflammation
Neurobiology Neurobiology Stem Cells & Differentiation Stem Cells & Differentiation
Wound Healing Wound Healing Allergy Allergy
Transplantation Transplantation  
 
 
Country of Origin:
USA


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