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Recombinant Human IL-4 貨號:AF-200-04 細胞因子

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Recombinant Human IL-4 貨號:AF-200-04 細胞因子
細胞因子(cytokine,CK)是一類能在細胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點:多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細介紹

Recombinant Human IL-4 貨號:AF-200-04 細胞因子 

 

細胞因子受體的結(jié)構(gòu)和分類:根據(jù)細胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征,可將細胞因子受體主要分為四種類型:免疫球蛋白超家族(IGSF)、造血細胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

 

Catalog Number:
AF-200-04
Synonyms:
BCGF, BCDF, B cell stimulating factor (BSF-1)
Description:
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues. Manufactured using all non-animal reagents.
AA Sequence:
MHKCDITLQE IIKTLNSLTE QKTLCTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
 
 
 
 
Cross Reactivity:
Human, Mouse
Research Interests:
Apoptosis Apoptosis Cancer Cancer
Cell Culture Cell Culture Immune System Immune System
Inflammation Inflammation Proliferation Proliferation
Stem Cells & Differentiation Stem Cells & Differentiation Allergy Allergy
Transplantation Transplantation  
 
 
Country of Origin:
USA


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