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Recombinant Human IL-1β 貨號:200-01B 細胞因子

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Recombinant Human IL-1β 貨號:200-01B 細胞因子
細胞因子(cytokine,CK)是一類能在細胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細介紹

Recombinant Human IL-1β 貨號:200-01B 細胞因子 

 

細胞因子受體的結(jié)構(gòu)和分類:根據(jù)細胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細胞因子受體主要分為四種類型：免疫球蛋白超家族（IGSF）、造血細胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

 

Catalog Number:
200-01B
Synonyms:
Catabolin, Lymphocyte-activating factor （LAF）, Endogenous Pyrogen （EP）, Leukocyte Endogenous Mediator （LEM）, Mononuclear Cell Factor （MCF）
Description:
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.
AA Sequence:
APVRSLNCTL RDSKSLVM SGPYELKALH LQGQDMEV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
 
 
 
 
Cross Reactivity:
Frog, Monkey, Mouse, Rabbit, Rat, Sheep, Human, Mouse + Chicken, Bacteria, Cow, Human + Rat, Pig, Insect
Research Interests:
Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular Cancer Cancer
Diabetes / Weight Regulation Diabetes / Weight Regulation Immune System Immune System
Inflammation Inflammation Neurobiology Neurobiology
Proliferation Proliferation Stem Cells & Differentiation Stem Cells & Differentiation
Wound Healing Wound Healing Allergy Allergy
Transplantation Transplantation  
 
 
Country of Origin:
USA


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