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Recombinant Human IGF-1 貨號(hào):100-11 細(xì)胞因子

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Recombinant Human IGF-1 貨號(hào):100-11 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human IGF-1 貨號(hào):100-11 細(xì)胞因子

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細(xì)胞因子受體主要分為四種類型：免疫球蛋白超家族（IGSF）、造血細(xì)胞因子受體超家族、神經(jīng)生長(zhǎng)因子受體超家族和趨化因子受體。

Catalog Number:

100-11

Synonyms:

Insulin-like Growth Factor-I, Somatamedin C, IGF-IA

Description:

The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor （IGF-IR）, but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

AA Sequence:

GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Cross Reactivity:

Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A

Research Interests: