蛋白名稱:ERBB2人重組蛋白，10004-H02H
蛋白構(gòu)建:A DNA sequence encoding the extracellular domain (Met 1-Thr 652) of human ErbB2 (NP_004439.2) was fused with the Fc region of human IgG1 at the C-terminus.
表達(dá)宿主:HEK293 Cells
蛋白純度:≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
蛋白活性:
1. Immobilized Recombinant Human HER2 / ErbB2 Protein (Fc Tag) (Cat: 10004-H02H) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 10.2-30.8 ng/mL (QC tested).
2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 µg/mL Anti-ErbB2/Her2 Monoclonal Antibody (Routinely tested).
蛋白內(nèi)毒素:< 1.0 EU per μg of the protein as determined by the LAL method
預(yù)測(cè)N端:Thr 23
蛋白分子量:The recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.
蛋白NP號(hào):NP_004439.2
蛋白氨基酸序列:Met1-Thr652
蛋白標(biāo)簽:C-human IgG1-Fc
歡迎去義翹神州網(wǎng)查看ERBB2人重組蛋白詳細(xì)信息。
義翹神州業(yè)務(wù)布局
義翹神州總部位于中國(guó)北京，在上海、廣州設(shè)立了分公司，于美國(guó)、歐洲、日本、中國(guó)蘇州、中國(guó)泰州建立了子公司，并在擁有幾十家經(jīng)銷商，致力于為客戶提供更加便捷、高效、優(yōu)質(zhì)、專業(yè)的服務(wù)。
我們的宗旨：
堅(jiān)持自主開發(fā)，不斷提升技術(shù)水平，為全生命科學(xué)研究和生物醫(yī)藥創(chuàng)新研發(fā)提供高質(zhì)量試劑和服務(wù)支撐，助力推動(dòng)健康事業(yè)發(fā)展，造福人類。
人才建設(shè)：
①人才隊(duì)伍：900+
②碩士及以上學(xué)歷人才：230+
我們的客戶
客戶涵蓋大學(xué)、科研院所、醫(yī)藥研發(fā)企業(yè)等國(guó)內(nèi)外各類生物研發(fā)單位
硬件設(shè)施
①超過20,000平米的研發(fā)生產(chǎn)中心
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