雙足平衡測(cè)試儀是通過大鼠、小鼠自身的平衡調(diào)節(jié)來評(píng)估疼痛程度的方法。

動(dòng)物的雙腳分別著力于兩塊不同的稱重板上正常鼠會(huì)將體重平均分配到兩只腳上兩個(gè)測(cè)重板的數(shù)據(jù)差值很小；如果其中一只腳存在發(fā)炎、病變或神經(jīng)疼痛根據(jù)嚴(yán)重程度老鼠會(huì)自發(fā)地將體重轉(zhuǎn)移到另外一只腳上導(dǎo)致兩塊測(cè)重板的重量出現(xiàn)相應(yīng)的差值。該方法在藥篩和安評(píng)中被廣泛應(yīng)用。

雙足平衡測(cè)量來評(píng)價(jià)疼痛與壓力測(cè)痛儀測(cè)量的結(jié)果具有很好的相關(guān)性。

功能

· 全自動(dòng)測(cè)試操作方便
· 觸屏操作USB導(dǎo)出數(shù)據(jù)Excel格式輸出
· 磁性腳墊設(shè)計(jì)易于組裝和清洗
· 適用于大鼠和小鼠

型號(hào)47883/47882

產(chǎn)品特點(diǎn)

被廣泛使用的方法

· 引用次數(shù)超過1500次；

· 測(cè)量后肢的重量分布該方法在新款的Ugo Basile設(shè)備中得到更新；

自動(dòng)測(cè)試功能 

· 具備自動(dòng)化開啟測(cè)量模式使整個(gè)實(shí)驗(yàn)過程更簡(jiǎn)單和省力；

觸屏操作和USB數(shù)據(jù)存儲(chǔ)功能

· 可以快速設(shè)定參數(shù)控制儀器和管理數(shù)據(jù)；

· 數(shù)據(jù)可直觀顯示；

· 附帶移動(dòng)U盤可以存儲(chǔ)所有測(cè)試數(shù)據(jù)（包括平均爪重標(biāo)準(zhǔn)偏差左右比率等）

· 數(shù)據(jù)能夠以圖表形式直觀實(shí)時(shí)；

結(jié)果精確可靠

· 高精度力傳感器分辨率為0.1g；

· 校正簡(jiǎn)單；

· 非常耐用沒有其它易損或需要經(jīng)常更換部件；

· 數(shù)據(jù)重現(xiàn)性好；

· 每次實(shí)驗(yàn)后結(jié)果可以自行篩選數(shù)據(jù)可通過軟件導(dǎo)出兼容EXCEL格式的文件；

便于清洗

· 磁性腳墊設(shè)計(jì)易容移除和固定；

· 平板式設(shè)計(jì)沒有死角容易清理；

大鼠和小鼠測(cè)試鼠籠

實(shí)時(shí)的測(cè)量數(shù)據(jù) 

用于將csv數(shù)據(jù)導(dǎo)出到PC的USB密鑰和各連接器

產(chǎn)品主要規(guī)格

小鼠雙足平衡測(cè)試儀

大鼠雙足平衡測(cè)定儀

雙足平衡測(cè)定儀的部分相關(guān)文獻(xiàn)

1.Argueta, Donovan A., et al. "Palmitoylethanolamide Attenuates Pain-like Behavior in Factor VIII Deficient Mice." Blood 140.Supplement 1 (2022)5578-5579.doi10.1182/blood-2022-159745
IF 25.48
2.Shi, Yuanyuan et al. “A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development." Nature communications vol. 10,1 1914. 23 Apr. 2019, doi:10.1038/s41467-019-09839-x
IF17.69
3.Cao, Chenxi et al. “Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4." Nature communications vol. 13,1 7139. 21 Nov. 2022, doi:10.1038/s41467-022-34830-4
IF17.69
4.Kwon, Hyuk-Kwon et al. “A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice." Experimental & molecular medicine vol. 51,4 1-19. 26 Apr. 2019, doi:10.1038/s12276-019-0244-0
IF12.15
5.Batchelor, V., J. Miotla-Zarebska, and T. L. Vincent. "REFINING METHODS TO MEASURE SPONTANEOUS PAIN BEHAVIOUR IN SURGICALLY INDUCED MURINE OSTEOARTHRITIS." Osteoarthritis and Cartilage 30 (2022)S381. doi10.1016/j.joca.2022.02.513
IF 7.51
6.Cheng, Jin, et al. "RIP1 perturbation induces chondrocyte necroptosis and promotes osteoarthritis pathogenesis via targeting BMP7." Frontiers in Cell and Developmental Biology 9 (2021)638382. doi:10.3389/fcell.2021.638382
IF 6.08
7.Sur, Bongjun et al. “Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative." Inflammation vol. 42,3 (2019)928-936. doi:10.1007/s10753-018-0947-8
IF4.66
8.Villa, Thea et al. “Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1β-Stimulated Human FLS Cells." Biomolecules & therapeutics vol. 28,5 (2020)414-422. doi:10.4062/molther.2020.113
IF4.23
9.Carlesso, Lisa C et al. “Use of IMMPACT Recommendations to Explore Pain Phenotypes in People with Knee Osteoarthritis." Pain medicine (Malden, Mass.) vol. 23,10 (2022)1708-1716. doi:10.1093/pm/pnac044
IF3.64
10.Surcheva, Slavina, et al. "Preclinic and clinic effectiveness of gabapentin and pregabalin for treatment of neuropathic pain in rats and diabetic patients." Biotechnology & Biotechnological Equipment 31.3 (2017)568-573.doi10.1080/.2017.1290550
IF:1.77
11.Miotla-Zarebska, Jadwiga et al. “Modeling and Assessing Osteoarthritis in Mice by Destabilization of the Medial Meniscus (DMM)." Methods in molecular logy (Clifton, N.J.) vol. 2598 (2023)357-373. doi:10.1007/978-1-0716-2839-3_26
IF0.39

    3007536621