大鼠、小鼠睡眠剝奪儀是一款不需要對(duì)動(dòng)物進(jìn)行訓(xùn)練以溫和的方式對(duì)動(dòng)物進(jìn)行睡眠限制的儀器。 參數(shù)設(shè)定完成后不需要人為的干預(yù)即可對(duì)大鼠或小鼠進(jìn)行睡眠剝奪的實(shí)驗(yàn)。可用于睡眠研究、時(shí)差研究和間斷性睡眠模型模擬。

產(chǎn)品特點(diǎn)

· 具有四種工作模式常開(kāi)、定時(shí)、間歇、正反轉(zhuǎn)；

· 轉(zhuǎn)棒轉(zhuǎn)動(dòng)溫和不會(huì)對(duì)動(dòng)物造成任何機(jī)械損傷；

· 定時(shí)模式可設(shè)置干擾棒轉(zhuǎn)動(dòng)的時(shí)間；

· 間歇模式可分別調(diào)節(jié)轉(zhuǎn)動(dòng)時(shí)間和停止時(shí)間；

· 正反轉(zhuǎn)模式可以定時(shí)設(shè)置干擾棒的運(yùn)轉(zhuǎn)方向；

· 轉(zhuǎn)棒高度可調(diào)減少墊料的影響；

· 根據(jù)實(shí)驗(yàn)需求選配大鼠型、小鼠型活動(dòng)籠；

· 我們也可以提供定制化改進(jìn)服務(wù)；

型號(hào)YAN-239

可根據(jù)需要選擇水槽式睡眠剝奪箱

型號(hào)SY-M3100小鼠6個(gè)平臺(tái)

           SY-M3040小鼠40個(gè)平臺(tái)

           SY-R3020大鼠15個(gè)平臺(tái)

           更多型號(hào)請(qǐng)

小鼠的水槽式睡眠和疲勞剝奪正在進(jìn)行中

部分參考文獻(xiàn)

1. Cordeira, J., Kolluru, S.S., Rosenblatt, H., Kry, J., Strecker, R.E., McCarlet, R.W. (2017). Learning and memory are impaired in the object recognition

task during metestrus/diestrus and after sleep deprivation. Behavioural Brain Research, 339, 124-129. doi10.1016/j.bbr.2017.11.033

2. Hines, D.J., Schmitt, L.I., Hines, R.M., Moss, S.J., & Haydon, P.G. (2013). Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Translational Psychiatry, 3, e212. doi10.1038/tp.2012.136

3. Lee, D., Lee, S., & Sohn, D. (2016). MP86-19 effect of sleep deprivation on hormonal axis and erectile function. Journal of Urology, 195(4), e1113. doi:10.1016/j.juro.2016.02.2327

4. Lee, D.S., Sohn, D.W., Yoon, B.I., & Yoo, J.M. (2017). 383 effect of sleep deprivation on hormonal axis and erectile function. Journal of Sexual Medicine, 14(1), S113-S114. doi10.1016/j.jsxm.2016.11.264

5. Naidoo, N., Davis, J.G., Zhu, J., Yabumoto, M., Singletary, K., Brown, M., … & Baur, J.A. (2014). Aging and sleep deprivation induce the unfolded protein response in the pancreasimplications for metabolism. Aging Cell, 13(1), 131-141. doi10.1111/acel.12158

6. Schmidt, M.A. & Wisor, J.P. (2012). Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence. Neuroscience Letters, 513(2), 209-213. doi10.1016/j.neulet.2012.02.040

7. Ward, C.P., Wooden, J.I., & Kieltyka, R. (2017). Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats. Psychology & Neuroscience, 10(1), 109-116. doi10.1037/pne0000075

8. Wooden, J., Pido, J., Mathews, H., Kieltyka, R., Montemayor, B., & Ward, C. (2014). Sleep deprivation impairs recall of social transmission of food preference in rats. Nature and Science of Sleep, 2014(6), 129-135. doi10.2147/NSS.S68611

9. Duncan, M. J., L. E. Guerriero, K. Kohler, L. E. Beechem, B. D. Gillis, F. Salisbury, C. Wessel, J. Wang, S. Sunderam, A. D. Bachstetter, B. F. O’Hara and M. P. Murphy, 2022. Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer’s Disease. Neuroscience 481111-122.

10. Robinson-Junker, A., O’Hara, B., Durkes, A., Gaskill, B., 2019. Sleeping through anythingThe effects of unpredictable disruptions on mouse sleep, healing, and affect. PloS one 14, e0210620.