CAS號(hào)	72909-34-3	產(chǎn)地	國(guó)產(chǎn)
規(guī)格	5mg	級(jí)別	化工級(jí)
證書(shū)	ISO系列證書(shū)

Pyrroloquinoline quinone (Synonyms: 吡咯喹啉醌; Methoxatin)

Pyrroloquinoline quinone 是氧化還原輔助因子，一種陰離子型氧化還原循環(huán)原醌。Pyrroloquinoline quinone 最初是從嗜甲基細(xì)菌的培養(yǎng)物中分離的，也存在于哺乳動(dòng)物的組織。Pyrroloquinoline quinone 是哺乳動(dòng)物的必需營(yíng)養(yǎng)素，對(duì)免疫功能很重要。

生物活性

Pyrroloquinoline quinone , a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function^[1]^[2].

IC₅₀ & Target^[1]

Human Endogenous Metabolite

體外研究(In Vitro)

Mouse pups born to and nursing from Pyrroloquinoline quinone-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms^[2].

分子量：330.21

Formula：C₁₄H₆N₂O₈

CAS 號(hào)：72909-34-3

中文名稱(chēng)：吡咯喹啉醌；吡咯并喹啉苯醌

來(lái)源：prokaryotes

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式：

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

In Vitro:

H₂O : 1 mg/mL (3.03 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.0284 mL	15.1419 mL	30.2838 mL
5 mM	---	---	---
10 mM	---	---	---

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

參考文獻(xiàn)

[1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.

[2]. Bishop A, et al. Methoxatinin guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.

注：產(chǎn)品僅用于科研