CAS號(hào)	13721-39-6	產(chǎn)地	國(guó)產(chǎn)
規(guī)格	500mg	級(jí)別	化工級(jí)
證書(shū)	ISO系列證書(shū)

Sodium orthovanadate (Synonyms: 釩酸鈉)

Sodium orthovanadate是蛋白酪an酸磷酸酶，堿性磷酸酶和一些ATP酶的抑制劑，Z有可能充當(dāng)磷酸鹽類似物。

生物活性

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

IC₅₀ & Target

PPTPase^[1].

體外研究(In Vitro)

In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO4^2- or H2VO^4-) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process^[1]. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia^[2].

分子量：183.91

Formula：Na₃O₄V

CAS 號(hào)：13721-39-6

中文名稱：正釩酸鈉；原釩酸鈉；釩酸鈉

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)

In Vitro:

H₂O : 8.33 mg/mL (45.29 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	5.4374 mL	27.1872 mL	54.3744 mL
5 mM	1.0875 mL	5.4374 mL	10.8749 mL
10 mM	0.5437 mL	2.7187 mL	5.4374 mL

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

注：產(chǎn)品僅用于科研