Flecainide

Flecainide 是一種有效的具有口服活性的抗心律失常劑。Flecainide 阻斷心臟快速內向 Na⁺ 電流 (INa) 和延遲整流器 K⁺ 電流的快速成分。Flecainide 可延長心室和心房肌纖維的動作電位持續(xù)時間 (APD)。Flecainide 具有研究胎兒心動過速的潛力。

生物活性

Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na⁺ current (INa) and the rapid component of the delayed rectifier K⁺ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias^[1][2][3].

分子量：414.34

Formula：C₁₇H₂₀F₆N₂O₃

CAS 號：54143-55-4

運輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

參考文獻

[1]. Echt DS, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991 Mar 21;324(12):781-8.

[2]. Aliot E, et al. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73.

[3]. Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8.

注：產(chǎn)品僅用于科研