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(±)-Carnitine chloride 返回列表頁

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型號
HY-B1453
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

500mg 400元 10000支可售

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MCE: 抑制劑生物試劑

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產(chǎn)品簡介

CAS號	461-05-2	產(chǎn)地	國產(chǎn)
規(guī)格	500mg	級別	化工級
證書	ISO系列證書

(±)-Carnitine chloride 有D和L兩種異構(gòu)體。L-carnitine在脂肪酸的β-氧化中起重要作用，也具有抗氧化作用和抗yan活性。

詳情介紹

(±)-肉堿氯化物 (Synonyms: DL-Carnitine chloride)

(±)-Carnitine chloride 有D和L兩種異構(gòu)體。L-carnitine在脂肪酸的β-氧化中起重要作用，也具有抗氧化作用和抗yan活性。

生物活性

(±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.

體外研究(In Vitro)

The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine^[1]. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H₂O₂-treated HL7702 cells. L-carnitine protects HL7702 cells against H₂O₂-induced cell damage through Akt-mediated activation of Nrf2 signaling pathway^[2].

體內(nèi)研究(In Vivo)

L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy^[3]. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ^[4].

分子量：197.66

Formula：C₇H₁₆ClNO₃

CAS 號：461-05-2

中文名稱：混旋肉堿鹽酸鹽；DL-肉堿鹽酸鹽

來源：Human muscle

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)

In Vitro:

H₂O : ≥ 100 mg/mL (505.92 mM)

DMSO : 25 mg/mL (126.48 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制儲備液

1 mM	5.0592 mL	25.2960 mL	50.5919 mL
5 mM	1.0118 mL	5.0592 mL	10.1184 mL
10 mM	0.5059 mL	2.5296 mL	5.0592 mL

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲存時(shí)，請?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲存時(shí)，請?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請根據(jù)您的實(shí)驗(yàn)動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請依序添加每種溶劑： PBS
Solubility: 150 mg/mL (758.88 mM); Clear solution; Need ultrasonic
2.

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution
3.

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution
4.

請依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution

參考文獻(xiàn)

[1]. Oyanagi E, et al. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acidstress. Biochem Biophys Res Commun. 2011 Aug 19;412(1):61-7. [Content Brief]
[2]. Li J, et al. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can J Physiol Pharmacol. 2016 May;94(5):517-25. [Content Brief]
[3]. Jang J, et al. l-Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats. Appl Physiol Nutr Metab. 2016 Dec;41(12):1240-1247. [Content Brief]
[4]. Zambrano S, et al. L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. Am J Hypertens. 2014 Mar;27(3):460-70. [Content Brief]

注：產(chǎn)品僅用于科研