IGF-I/IGF-1 蛋白, Human (70a.a)

IGF-I/IGF-1 蛋白, Human (70a.a)是一種促進(jìn)有絲分裂的細(xì)胞因子，與 IGF 受體結(jié)合，能夠調(diào)節(jié)多種組織的生長(zhǎng)，如神經(jīng)組織、淋巴組織、生殖組織、平滑肌、內(nèi)皮細(xì)胞和骨骼等，同時(shí)具有調(diào)節(jié)神經(jīng)保護(hù)的作用。

描述

IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.

研究背景

Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts^[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice^[2].

種屬：Human

表達(dá)系統(tǒng)：E. coli

標(biāo)簽：Tag Free

蛋白編號(hào)：P05019 (G49-A118)

基因 ID：3479  [NCBI]

同用名：rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

氨基酸序列

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

分子量：Approximately 7.7 kDa

純度：Greater than 95% as determined by reducing SDS-PAGE.

性狀：Lyophilized powder.

組分：Lyophilized after extensive dialysis against PBS.

復(fù)溶方法：It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

保存條件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

參考文獻(xiàn)

• [1]. Richman C, et al. Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. Endocrinology. 1999 Oct;140(10):4699-705.  [Content Brief]

  [2]. Carlson SW, et al. Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury. J Neurotrauma. 2018 Jul 1;35(13):1467-1480.  [Content Brief]

注：產(chǎn)品僅用于科研