Oligomycin  (Synonyms: 寡霉素)

Oligomycin 是一種抗真jun抗生su，是 H+-ATP 合成酶的抑制劑。Oligomycin 斷氧化磷酸化和電子傳遞鏈。Oligomycin 抑制缺氧性腫瘤細(xì)胞 HIF-1alpha 表達(dá)。

生物活性

Oligomycin, an antifungal antibiotic, is an inhibitor of H⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells

體外研究(In Vitro)

Oligomycin, inhibitor of the F0 part of H⁺-ATP-synthase, suppresses the TNF-induced apoptosis^[1].

性狀：Solid

CAS 號(hào)：1404-19-9

中文名稱：寡霉素

來源

Streptomyces

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)

In Vitro: 

參考文獻(xiàn)

[1]. Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796.  [Content Brief]

[2]. SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.  [Content Brief]

[3]. López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.  [Content Brief]

[4]. Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029.  [Content Brief]

[5]. Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157.  [Content Brief]

注：產(chǎn)品僅用于科研