IFN-gamma 蛋白, Mouse

IFN-gamma 蛋白, Mouse是一種促炎性細(xì)胞因子，具有高效的免疫調(diào)節(jié)功能，同時(shí)可抗細(xì)胞增殖，抗病毒等。

描述

IFN-gamma Protein, Mouse is a pro-inflammatory cytokine with potent immunomodulatory, anti-proliferative, and antiviral properties.

研究背景

Interferon-gamma (IFN-γ) is a cytokine with potent immunomodulatory, anti-proliferative, and antiviral properties. IFN-γ activates cells via a different receptor than IFN-α and IFN-β, which accounts for the different physiological properties of the proteins. Production of IFN-γ is largely restricted to activated CD4⁺ TH1 T cells, CD8⁺ T cells, and natural killer cells. One of the most important consequences of IFN-γ secretion is the activation of macrophages. In addition, IFN-γ plays a central role in inflammatory responses by activating endothelial cells, promoting TH1 cell development and cellular immune responses, and up-regulation of major histocompatability complex protein expression on antigen-presenting cells^[1].

生物活性

Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED₅₀ is < 0.15 ng/mL.

種屬：Mouse

表達(dá)系統(tǒng)：E. coli

標(biāo)簽：Tag Free

蛋白編號(hào)：P01580 (H23-C155)

基因 ID：15978  [NCBI]

中文名：重組小鼠干擾素-γ

同用名：rMuIFN-γ; IFNG; IFN-gamma; Interferon gamma

氨基酸序列

MHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC

分子量：Approximately 15 kDa

純度：Greater than 95% as determined by reducing SDS-PAGE.

性狀：Lyophilized powder

組分：Lyophilized after extensive dialysis against PBS.

復(fù)溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O or PBS.

保存條件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

參考文獻(xiàn)

[1]. Fam CM, et al. PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice. J Interferon Cytokine Res. 2014 Oct;34(10):759-68.  [Content Brief]