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Cyclosporin A(環(huán)bao素) 返回列表頁

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參考價:520

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型號
HY-B0579
品牌
MCE
廠商性質
代理商
所在地
杭州市

規(guī)格

100mg 520元 10000支可售

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MCE: 抑制劑生物試劑

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產品簡介

產地	國產	規(guī)格	100mg
級別	化工級	證書	ISO系列證書

Cyclosporin A (Cyclosporine A) 是一種免疫抑制劑，能與親環(huán)素結合，抑制 calcineurin 活性的IC50 值為 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。

詳情介紹

Cyclosporin A (Synonyms: 環(huán)bao素; Cyclosporine A; Ciclosporin A; CsA)

Cyclosporin A (Cyclosporine A) 是一種免疫抑制劑，能與親環(huán)素結合，抑制 calcineurin 活性的IC₅₀ 值為 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。

生物活性

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC₅₀ of 5 nM^[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion^[8].

IC₅₀ & Target

IC50: 7 nM (calcineurin)

體外研究(In Vitro)

Cyclosporin A is able to bind with the cyclophilin in T cells^[1]. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin^[2]. Cyclosporin A inhibits calcineurin in stimulated cells with an IC₅₀ value of 7 nM^[3]. Cyclosporin A suppresses the nuclear translocation of NF-AT^[4]. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC₅₀ of 39 nM^[5].

體內研究(In Vivo)

Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs^[6]. Cyclosporin A can be used in organ transplantation to prevent rejection^[7].

分子量：1202.61

性狀：Solid

Formula：C₆₂H₁₁₁N₁₁O₁₂

CAS 號：59865-13-3

中文名稱：huan孢霉素A；環(huán)孢suA；環(huán)bao多肽A；環(huán)孢靈；賽斯平；環(huán)bao素

來源：the fungus Beauveria nivea.

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數據

In Vitro:

DMSO : 62.5 mg/mL (51.97 mM; Need ultrasonic)

Ethanol : 50 mg/mL (41.58 mM; Need ultrasonic)

配制儲備液

濃度溶劑體積質量	1 mg	5 mg	10 mg

1 mM	0.8315 mL	4.1576 mL	8.3152 mL
5 mM	0.1663 mL	0.8315 mL	1.6630 mL
10 mM	0.0832 mL	0.4158 mL	0.8315 mL

請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲存時，請在 6 個月內使用，-20°C 儲存時，請在 1 個月內使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結果的可靠性，澄清的儲備液可以根據儲存條件，適當保存；體內實驗的工作液，建議您現用現配，當天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的方式助溶

1.

請依序添加每種溶劑： corn oil
Solubility: 20 mg/mL (16.63 mM); Clear solution; Need ultrasonic
2.

請依序添加每種溶劑： 5% DMSO 40% PEG300 5% Tween-80 50% saline
Solubility: 2.62 mg/mL (2.18 mM); Suspended solution; Need ultrasonic
3.

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 2.08 mg/mL (1.73 mM); Suspended solution; Need ultrasonic
4.

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (1.73 mM); Suspended solution; Need ultrasonic
5.

請依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (1.73 mM); Clear solution

參考文獻

[1]. Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. [Content Brief]

[2]. Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. [Content Brief]

[3]. Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3686-90. [Content Brief]

[4]. Flanagan WM, et al. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991 Aug 29;352(6338):803-7. [Content Brief]

[5]. Nicolli A, et al. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem. 1996 Jan 26;271(4):2185-92. [Content Brief]

[6]. Borel JF, et al. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology. 1977 Jun;32(6):1017-25. [Content Brief]

[7]. Williams, R, et al. Randomised trial comparing FK506 and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. Lancet, 1994, 344(8920), 423-428. [Content Brief]

[8]. Dalmarco EM, et al. Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. Cell Adh Migr. 2008 Oct-Dec;2(4):231-5. [Content Brief]

注：產品僅用于科研