操得我好爽,亚洲区偷拍区

產(chǎn)地	進(jìn)口	級別	其他

注：本產(chǎn)品僅用于科研，不可用于臨床

生物活性

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

體外研究
(In Vitro)

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP promotes neutrophil chemotaxis in vitro^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4].
ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four-week-old Kunming mice (18-22 g)^[4]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, before bacterial (E. coli) challenge
Result:	Protected mice from bacterial infection.

分子量

507.18

性狀

Solid

Formula

C₁₀H₁₆N₅O₁₃P₃

CAS 號

56-65-5

中文名稱

腺苷三磷酸

結(jié)構(gòu)分類

Alkaloids
Other Alkaloids

來源

Plants
other families

widespread

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

In Vitro:

H₂O : ≥ 100 mg/mL (197.17 mM)

* "≥" means soluble, but saturation unknown.

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	1.9717 mL	9.8584 mL	19.7169 mL
5 mM	0.3943 mL	1.9717 mL	3.9434 mL
10 mM	0.1972 mL	0.9858 mL	1.9717 mL

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時(shí)，請?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲存時(shí)，請?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請根據(jù)您的實(shí)驗(yàn)動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶