Gibco CTS OpTmizer T-Cell Expansion SFM supports the growth and expansion of human T lymphocytes. It is a complete serum-free, xeno-free medium consisting of CTS OpTmizer T-Cell Expansion Basal Medium and CTS OpTmizer T-Cell Expansion Supplement, which are mixed together prior to use.
CTS OpTmizer T-Cell Expansion SFM in 5 L and 10 L bag format is compatible with closed-system processing for media preparation. 5 L and 10 L volumes support scaling of cell therapy manufacturing workflows. The updated bag format allows for easier integration with standard cell therapy equipment, including CTS devices (Xenon, Rotea, and DynaCellect).
Features of CTS OpTmizer T-Cell Expansion SFM include:
• Both kit components (medium and supplement) in Aegis5-14 film bags
• Weldable C-Flex and PVC lines
• Supports high-density T-cell culture (>4 x 106 CD3+ T cells/mL)
• Supports T-cell activation using Dynabeads magnetic beads, soluble antibodies, and stimulatory antibody-presenting cell protocols
• Similar phenotype, function (e.g., cytokine secretion profile), and viability to T cells cultured with conventional human AB serum–supplemented medium
• Supports a T-cell phenotype similar to human serum–supplemented medium
• Demonstrates enhanced efficacy and persistence of CART-19 cells when grown in medium supplemented with CTS Immune Cell Serum Replacement (ICSR)
Benefits include:
• Prepare complete medium in a closed system with weldable lines
• Reduces open steps and contamination risks
• Easy integration with CTS automated instrumentation
Demonstrated functional performance
Cells grown in CTS OpTmizer T-Cell Expansion SFM with or without human serum demonstrate good cytokine production profiles in polyclonally activated T cells. CTS OpTmizer T-Cell Expansion SFM maintains the desired the CD62L+ central memory T-cell phenotype.
GMP manufactured
The primary manufacturing site for CTS OpTmizer T-Cell Expansion SFM is FDA-registered and has an ISO13485–certified quality management system. The methods and controls used for the manufacturing are in conformity with current Good Manufacturing Practices for medical devices, 21 CFR Part 820, of the regulation.
Versatility
CTS OpTmizer T-Cell Expansion SFM has been widely adopted in clinical T-cell research applications including the culture of CAR T-cells. It works with multiple culture formats: culture flasks, culture bags, and automated and scalable bioreactors. CTS OpTmizer T-Cell Expansion SFM was designed to support expansion of cultured human T-cells without additional serum supplementation. Increased performance is generally observed when supplemented with CTS Immune Cell Serum Replacement.
賽默飛世爾科技中國簡介
賽默飛世爾科技進(jìn)入中國發(fā)展已超過35年，在中國的總部設(shè)于上海，并在北京、廣州、香港、成都、沈陽、西安、南京、武漢、昆明等地設(shè)立了分公司，員工人數(shù)約為5000名。我們的產(chǎn)品主要包括分析儀器、實(shí)驗(yàn)室設(shè)備、試劑、耗材和軟件等，提供實(shí)驗(yàn)室綜合解決方案，為各行各業(yè)的客戶服務(wù)。
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