產(chǎn)品和服務(wù)涵蓋生命科學(xué)研究技術(shù)的諸多方面，提供覆蓋分子生物學(xué)、細(xì)胞生物學(xué)、植物學(xué)、生物化學(xué)、蛋白組學(xué)、免疫學(xué)等領(lǐng)域的實(shí)驗(yàn)產(chǎn)品以及生物技術(shù)服務(wù)等。目前一級(jí)代理品牌有：MCE（Medchemexpress）、Biochannel、AATbio、invivogen、Abnova、Atlas、Origene、Biovision、云克隆（Cloud-clone）、艾德萊(Aidlab)、Cayman、Jackson、Epigentek、Prospec、Sciencell、icellbioscience（賽百慷）、hkABCbio、chondrex、Mybiosource、Abbexa、Innovrsrch、HPI、Hitobiotec、Greerlabs，Ostex，4ADI，LDN等。

經(jīng)營(yíng)理念：以誠(chéng)信為本，保證產(chǎn)品質(zhì)量求生存，創(chuàng)造企業(yè)核心競(jìng)爭(zhēng)力求發(fā)展 , 堅(jiān)持用戶(hù)至上、服務(wù)至上的原則。

展開(kāi)顯示更多內(nèi)容

胎牛血清、MCE抑制劑激動(dòng)劑、RNA提取試劑盒、ELISA試劑盒、重組蛋白

產(chǎn)品簡(jiǎn)介在線詢(xún)價(jià)

產(chǎn)地	進(jìn)口	規(guī)格	100ul
級(jí)別	化工級(jí)	證書(shū)	ISO系列證書(shū)

該抗體是針對(duì)HMGB1的兔多克隆抗體。在免疫組織化學(xué)染色和免疫印跡實(shí)驗(yàn)中能識(shí)別HMGB1。

高遷移率族蛋白1(HMGB1)多克隆抗體產(chǎn)品信息

高遷移率族蛋白1(HMGB1)多克隆抗體

Polyclonal Antibody to High Mobility Group Protein 1 (HMGB1)

HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein

編號(hào)PAA399Ra01
物種Rattus norvegicus (Rat，大鼠) 相同的名稱(chēng)，不同的物種。
來(lái)源多抗制備
宿主兔
效價(jià)-
Ig類(lèi)型IgG
純化方式抗原特異性親和純化
標(biāo)記物無(wú)標(biāo)記物
免疫原RPA399Ra01-高遷移率族蛋白1(HMGB1)重組蛋白
緩沖液成份0.01M 磷酸鹽緩沖液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
性狀液體
濃度0.34mg/ml
且適物種Homo sapiens (Human，人), Mus musculus (Mouse，小鼠)
應(yīng)用WB,IHC
如果抗體需用于流式細(xì)胞術(shù)，請(qǐng)參見(jiàn)流式抗體。
下載英文說(shuō)明書(shū) 中文說(shuō)明書(shū)
規(guī)格20µl100µl 200µl 1ml 10ml
價(jià)格￥ 1436

特異性

該抗體是針對(duì)HMGB1的兔多克隆抗體。在免疫組織化學(xué)染色和免疫印跡實(shí)驗(yàn)中能識(shí)別HMGB1。

用法

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

儲(chǔ)存

經(jīng)常使用則4°C保存。-20°C保存不超過(guò)兩年。避免反復(fù)凍融。

穩(wěn)定性

熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時(shí)，沒(méi)有明顯的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲(chǔ)，損失率低于5%。

參考文獻(xiàn)

雜志	參考文獻(xiàn)
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine	High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis [PubMed: PMC3094252]
Respiration	Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice [Karger: 000319151]
Surgery	Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in Southwest China [Pubmed: 22047946]
Viral Immunology	Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source]
Chinese Medical Journal	Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats [CMJ: 2009218808935901080]
Microbiology and Immunology	Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis [PubMed: 23278480]
ACTA biochimica polonica	High mobility group B1 levels in sepsis and disseminated intravascular coagulation [Actabp: Source]
Anesthesia and Analgesia	The Inhibitory Effect of Lidocaine on the Release of High Mobility Group Box 1 in Lipopolysaccharide-Stimulated Macrophages [PubMed: 21288974]
Rheumatology International	Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life [PubMed: 23143556]
Inflammation Research	Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279]
Acta Biochimica et Biophysica Sinica	IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PubMed: 22782142]
LabVest	The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head. [PubMed: 22825687]
Biomark Insights	Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism [PubMed: PMC3623607]
Evidence-based Complementary and Alternative Medicine	ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression [PubMed: PMC3770047]
Exp Ther Med	Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease [Pubmed: 23935732]
International of Rheumatic disesases	Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia [Pubmed: 23901875]
Surgery	A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034]
Acta Pharmacol Sin.	Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis [Pubmed: 23564080]
BMC pulmonary medicine	Soluble receptor for advanced glycation end-products and progression of airway disease [Pubmed: 24758342]
Biochemical Pharmacology	Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [Pubmed:25896849]